Maximizing the benefits of off-target kinase inhibitor activity.
نویسندگان
چکیده
Investigators report the identification of novel mutant-specific inhibition of EGF receptor (EGFR) T790M by bis-indole-based inhibitors of protein kinase C using a small-molecule cancer cell line-based screening platform. This study shows the power of high-throughput drug screening in cancer cell lines and provides new lead scaffolds for optimization against resistant EGFR mutants in lung cancer.
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ورودعنوان ژورنال:
- Cancer discovery
دوره 3 2 شماره
صفحات -
تاریخ انتشار 2013